| Reaction Details |
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 | Report a problem with these data |
| Target | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
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| Ligand | BDBM50443771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280332 (CHEMBL3095347) |
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| Kd | 148000±n/a nM |
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| Citation |  Zhang, Z; Jakkaraju, S; Blain, J; Gogol, K; Zhao, L; Hartley, RC; Karlsson, CA; Staker, BL; Edwards, TE; Stewart, LJ; Myler, PJ; Clare, M; Begley, DW; Horn, JR; Hagen, TJ Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg Med Chem Lett23:6860-3 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
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| Name: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
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| Synonyms: | ISPF_BURPS | MECDP-synthase | MECPP-synthase | MECPS | ispF | mecS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17174.90 |
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| Organism: | Burkholderia pseudomallei (strain K96243) |
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| Description: | ChEMBL_107981 |
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| Residue: | 162 |
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| Sequence: | MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIG
RHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAA
DLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVREAAA
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| BDBM50443771 |
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| n/a |
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| Name | BDBM50443771 |
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| Synonyms: | CHEMBL3094103 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N6O5S |
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| Mol. Mass. | 406.416 |
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| SMILES | Nc1ccn([C@@H]2O[C@H](CNC(=O)Cc3cn4ccsc4n3)[C@@H](O)[C@H]2O)c(=O)n1 |r| |
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| Structure | 
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