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TargetCytochrome P450 2D6
LigandBDBM50443781
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280376 (CHEMBL3095536)
IC50 600±n/a nM
Citation Wilson, DMApps, JBailey, NBamford, MJBeresford, IJBriggs, MACalver, ARCrook, BDavis, RPDavis, SDean, DKHarris, LHeightman, TDPanchal, TParr, CAQuashie, NSteadman, JGSchogger, JSehmi, SSStean, TOTakle, AKTrail, BKWhite, TWitherington, JWorby, AMedhurst, AD The discovery of the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett23:6897-901 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50443781
n/a
NameBDBM50443781
Synonyms:CHEMBL3094120
TypeSmall organic molecule
Emp. Form.C22H27NO
Mol. Mass.321.4559
SMILESC(Oc1ccc2CCN(CCc2c1)C1CCCC1)c1ccccc1
Structure
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