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TargetHistamine H1 receptor
LigandBDBM50443786
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280381 (CHEMBL3095541)
Ki 1995±n/a nM
Citation Wilson, DMApps, JBailey, NBamford, MJBeresford, IJBriggs, MACalver, ARCrook, BDavis, RPDavis, SDean, DKHarris, LHeightman, TDPanchal, TParr, CAQuashie, NSteadman, JGSchogger, JSehmi, SSStean, TOTakle, AKTrail, BKWhite, TWitherington, JWorby, AMedhurst, AD The discovery of the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett23:6897-901 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50443786
n/a
NameBDBM50443786
Synonyms:CHEMBL3094215
TypeSmall organic molecule
Emp. Form.C22H34N2O
Mol. Mass.342.5182
SMILESC(COc1ccc2CCN(CC3CC3)CCc2c1)CN1CCCCC1
Structure
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