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TargetCasein kinase I isoform alpha
LigandBDBM50443871
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1277835 (CHEMBL3097769)
IC50 1500±n/a nM
Citation Fukunaga, KUehara, FAritomo, KShoda, AHiki, SOkuyama, MUsui, YWatanabe, KYamakoshi, KKohara, THanano, TTanaka, HTsuchiya, SSunada, SSaito, KEguchi, JYuki, SAsano, STanaka, SMori, AYamagami, KBaba, HHorikawa, TFujimura, M 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3ß inhibitors. Bioorg Med Chem Lett23:6933-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I isoform alpha
Name:Casein kinase I isoform alpha
Synonyms:CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:Serine/threonine-protein kinase
Mol. Mass.:38936.59
Organism:Homo sapiens (Human)
Description:P48729
Residue:337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50443871
n/a
NameBDBM50443871
Synonyms:CHEMBL3091536
TypeSmall organic molecule
Emp. Form.C19H18FN5O2
Mol. Mass.367.3769
SMILESCn1c(nc(cc1=O)-c1ccncn1)N1CCO[C@H](C1)c1ccc(F)cc1 |r|
Structure
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