| Reaction Details |
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 | Report a problem with these data |
| Target | Sonic hedgehog protein |
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| Ligand | BDBM50443891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1277855 (CHEMBL3097789) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Xin, M; Wen, J; Tang, F; Tu, C; Shen, H; Zhao, X The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors. Bioorg Med Chem Lett23:6777-83 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sonic hedgehog protein |
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| Name: | Sonic hedgehog protein |
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| Synonyms: | Hhg1 | SHH_MOUSE | Shh |
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| Type: | Protein |
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| Mol. Mass.: | 47784.50 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q62226 |
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| Residue: | 437 |
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| Sequence: | MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFL
TFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQR
VYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAH
RAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTW
LLDSETMHPLGMAVKSS
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| BDBM50443891 |
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| n/a |
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| Name | BDBM50443891 |
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| Synonyms: | CHEMBL3091550 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23F3N4O2 |
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| Mol. Mass. | 492.4923 |
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| SMILES | Cc1cc(nc(Nc2ccc(cc2)C(=O)Nc2c(C)cccc2C)n1)-c1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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