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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase receptor TYRO3 | ||
| Ligand | BDBM50444074 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1279517 (CHEMBL3097236) | ||
| IC50 | 21±n/a nM | ||
| Citation |  Zhang, W; Zhang, D; Stashko, MA; DeRyckere, D; Hunter, D; Kireev, D; Miley, MJ; Cummings, C; Lee, M; Norris-Drouin, J; Stewart, WM; Sather, S; Zhou, Y; Kirkpatrick, G; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem56:9683-92 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase receptor TYRO3 | |||
| Name: | Tyrosine-protein kinase receptor TYRO3 | ||
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY | ||
| Type: | Protein | ||
| Mol. Mass.: | 96894.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06418 | ||
| Residue: | 890 | ||
| Sequence: |
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| BDBM50444074 | |||
| n/a | |||
| Name | BDBM50444074 | ||
| Synonyms: | CHEMBL3092791 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H34N6O | ||
| Mol. Mass. | 398.545 | ||
| SMILES | CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN(C)C)cn1 |r,wU:11.10,wD:14.14,(-4.06,-43.37,;-2.72,-42.6,;-1.39,-43.37,;-.05,-42.6,;1.29,-43.37,;2.62,-42.6,;3.96,-43.37,;5.29,-42.6,;5.29,-41.05,;3.95,-40.29,;3.95,-38.75,;2.61,-37.98,;1.29,-38.75,;-.06,-37.98,;-.06,-36.44,;-1.39,-35.67,;1.29,-35.67,;2.61,-36.44,;2.63,-41.06,;6.62,-40.28,;7.95,-41.05,;9.28,-40.27,;9.27,-38.73,;10.6,-37.96,;11.94,-38.72,;13.26,-37.94,;11.95,-40.26,;7.93,-37.97,;6.6,-38.75,)| | ||
| Structure | 
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