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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50444065 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1279519 (CHEMBL3097238) | ||
| IC50 | 4.5±n/a nM | ||
| Citation |  Zhang, W; Zhang, D; Stashko, MA; DeRyckere, D; Hunter, D; Kireev, D; Miley, MJ; Cummings, C; Lee, M; Norris-Drouin, J; Stewart, WM; Sather, S; Zhou, Y; Kirkpatrick, G; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem56:9683-92 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50444065 | |||
| n/a | |||
| Name | BDBM50444065 | ||
| Synonyms: | CHEMBL3092800 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H30N6 | ||
| Mol. Mass. | 354.4924 | ||
| SMILES | CCCCNc1ncc(c(N[C@H]2CC[C@H](CN)CC2)n1)-c1ccccn1 |r,wU:11.10,wD:14.14,(31.68,-9.79,;33.01,-9.02,;34.35,-9.79,;35.68,-9.02,;37.01,-9.8,;38.35,-9.03,;39.68,-9.8,;41.02,-9.03,;41.01,-7.48,;39.68,-6.71,;39.67,-5.17,;38.34,-4.41,;37.01,-5.18,;35.67,-4.4,;35.67,-2.86,;34.34,-2.09,;34.34,-.55,;37.01,-2.09,;38.34,-2.86,;38.35,-7.48,;42.34,-6.7,;43.68,-7.47,;45,-6.7,;45,-5.16,;43.65,-4.39,;42.34,-5.16,)| | ||
| Structure | 
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