Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50444069 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1279519 (CHEMBL3097238) | ||
IC50 | 1.3±n/a nM | ||
Citation | Zhang, W; Zhang, D; Stashko, MA; DeRyckere, D; Hunter, D; Kireev, D; Miley, MJ; Cummings, C; Lee, M; Norris-Drouin, J; Stewart, WM; Sather, S; Zhou, Y; Kirkpatrick, G; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem56:9683-92 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
| ||
BDBM50444069 | |||
n/a | |||
Name | BDBM50444069 | ||
Synonyms: | CHEMBL3092796 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H34N6O | ||
Mol. Mass. | 410.5557 | ||
SMILES | CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC2CC2)cn1 |r,wU:11.10,wD:14.14,(20.96,-58.36,;22.3,-57.6,;23.63,-58.37,;24.96,-57.6,;26.3,-58.37,;27.63,-57.6,;28.96,-58.37,;30.3,-57.6,;30.3,-56.05,;28.96,-55.28,;28.96,-53.74,;27.62,-52.98,;26.29,-53.75,;24.96,-52.98,;24.96,-51.43,;23.62,-50.66,;26.29,-50.67,;27.62,-51.43,;27.63,-56.06,;31.63,-55.27,;32.96,-56.04,;34.29,-55.27,;34.28,-53.73,;35.61,-52.95,;36.95,-53.72,;38.28,-52.94,;39.81,-52.93,;39.04,-51.6,;32.94,-52.96,;31.61,-53.74,)| | ||
Structure |