| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50444140 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280886 (CHEMBL3095184) |
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| IC50 | 120±n/a nM |
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| Citation |  Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM50444140 |
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| n/a |
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| Name | BDBM50444140 |
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| Synonyms: | CHEMBL3093394 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16F4N2O3 |
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| Mol. Mass. | 384.3249 |
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| SMILES | OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F |r| |
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| Structure | 
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