| Reaction Details |
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 | Report a problem with these data |
| Target | Lipoprotein lipase |
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| Ligand | BDBM50444147 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280894 (CHEMBL3095192) |
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| IC50 | >33000±n/a nM |
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| Citation |  Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lipoprotein lipase |
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| Name: | Lipoprotein lipase |
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| Synonyms: | LIPD | LIPL_HUMAN | LPL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53173.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1280894 |
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| Residue: | 475 |
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| Sequence: | MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGV
AESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH
YPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKG
LCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQ
AFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDW
WSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
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| BDBM50444147 |
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| n/a |
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| Name | BDBM50444147 |
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| Synonyms: | CHEMBL3093396 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3NO4 |
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| Mol. Mass. | 409.3989 |
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| SMILES | OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCCOCc1ccccc1)C(F)(F)F |r| |
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| Structure | 
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