Reaction Details |
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Target | Lipoprotein lipase |
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Ligand | BDBM50444154 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1280894 (CHEMBL3095192) |
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IC50 | >33000±n/a nM |
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Citation | Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lipoprotein lipase |
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Name: | Lipoprotein lipase |
Synonyms: | LIPD | LIPL_HUMAN | LPL |
Type: | PROTEIN |
Mol. Mass.: | 53173.96 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1280894 |
Residue: | 475 |
Sequence: | MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGV
AESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH
YPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKG
LCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQ
AFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDW
WSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
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BDBM50444154 |
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n/a |
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Name | BDBM50444154 |
Synonyms: | CHEMBL3093303 |
Type | Small organic molecule |
Emp. Form. | C18H15F4NO3 |
Mol. Mass. | 369.3102 |
SMILES | OC(=O)c1cc(ccc1N1CC[C@H](C1)Oc1ccc(F)cc1)C(F)(F)F |r| |
Structure |
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