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TargetEndothelial lipase
LigandBDBM50444158
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280896 (CHEMBL3095194)
IC50 209±n/a nM
Citation Sun, SDean, RJia, QZenova, AZhong, JGrayson, CXie, CLindgren, ASamra, PSojo, Lvan Heek, MLin, LPercival, DFu, JMWinther, MDZhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelial lipase
Name:Endothelial lipase
Synonyms:EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:Protein
Mol. Mass.:56805.62
Organism:Homo sapiens (Human)
Description:Q9Y5X9
Residue:500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50444158
n/a
NameBDBM50444158
Synonyms:CHEMBL3093401
TypeSmall organic molecule
Emp. Form.C18H15F4N5O
Mol. Mass.393.3382
SMILESFc1ccc(O[C@H]2CCN(C2)c2ccc(cc2-c2nnn[nH]2)C(F)(F)F)cc1 |r|
Structure
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