Reaction Details |
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Target | Endothelial lipase |
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Ligand | BDBM50444158 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1280896 (CHEMBL3095194) |
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IC50 | 209±n/a nM |
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Citation | Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelial lipase |
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Name: | Endothelial lipase |
Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
Type: | Protein |
Mol. Mass.: | 56805.62 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5X9 |
Residue: | 500 |
Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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BDBM50444158 |
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n/a |
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Name | BDBM50444158 |
Synonyms: | CHEMBL3093401 |
Type | Small organic molecule |
Emp. Form. | C18H15F4N5O |
Mol. Mass. | 393.3382 |
SMILES | Fc1ccc(O[C@H]2CCN(C2)c2ccc(cc2-c2nnn[nH]2)C(F)(F)F)cc1 |r| |
Structure |
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