| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM50444186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1277675 (CHEMBL3096917) |
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| IC50 | 80±n/a nM |
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| Citation |  Kuzmich, D; Bentzien, J; Betageri, R; DiSalvo, D; Fadra-Khan, T; Harcken, C; Kukulka, A; Nabozny, G; Nelson, R; Pack, E; Souza, D; Thomson, D Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists. Bioorg Med Chem Lett23:6640-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 107076.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08235 |
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| Residue: | 984 |
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| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
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| BDBM50444186 |
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| n/a |
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| Name | BDBM50444186 |
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| Synonyms: | CHEMBL3093445 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F3N2O2S |
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| Mol. Mass. | 424.48 |
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| SMILES | Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cc1c[nH]c2cccc(C)c12)C(F)(F)F |
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| Structure | 
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