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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50444242 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1277932 (CHEMBL3094776) | ||
| IC50 | 5.2±n/a nM | ||
| Citation |  Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50444242 | |||
| n/a | |||
| Name | BDBM50444242 | ||
| Synonyms: | CHEMBL3093755 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H32N6O4S | ||
| Mol. Mass. | 476.592 | ||
| SMILES | CCCCNc1ncc(C(=O)NCc2ccc(cc2)S(N)(=O)=O)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.25,wD:28.29,(24.27,-9.22,;25.6,-8.45,;26.93,-9.22,;28.27,-8.45,;29.6,-9.22,;30.94,-8.45,;32.27,-9.22,;33.61,-8.45,;33.6,-6.9,;34.93,-6.12,;34.93,-4.58,;36.27,-6.89,;37.6,-6.11,;38.94,-6.88,;38.94,-8.42,;40.27,-9.18,;41.6,-8.41,;41.59,-6.86,;40.26,-6.1,;42.94,-9.17,;44.27,-8.39,;43.7,-10.5,;42.17,-10.5,;32.27,-6.14,;32.26,-4.6,;30.93,-3.83,;29.59,-4.61,;28.25,-3.84,;28.25,-2.29,;26.92,-1.52,;29.59,-1.53,;30.92,-2.29,;30.94,-6.91,)| | ||
| Structure | 
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