| Reaction Details |
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 | Report a problem with these data |
| Target | Myeloblastin |
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| Ligand | BDBM50084637 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1278123 (CHEMBL3095811) |
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| IC50 | >100000±n/a nM |
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| Citation |  Lucas, SD; Gonçalves, LM; Carvalho, LA; Correia, HF; Da Costa, EM; Guedes, RA; Moreira, R; Guedes, RC Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors. J Med Chem56:9802-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myeloblastin |
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| Name: | Myeloblastin |
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| Synonyms: | Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27816.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1463425 |
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| Residue: | 256 |
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| Sequence: | MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL
LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF
FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV
DWIRSTLRRVEAKGRP
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| BDBM50084637 |
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| n/a |
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| Name | BDBM50084637 |
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| Synonyms: | 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester | 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester(ONO-5046) | CHEMBL76688 | ONO-5046 | Sivelestat |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O7S |
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| Mol. Mass. | 434.463 |
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| SMILES | CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O |
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| Structure | 
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