| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM50444317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1278248 (CHEMBL3096507) |
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| IC50 | 6.0±n/a nM |
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| Citation |  Hilpert, H; Mauser, H; Humm, R; Anselm, L; Kuehne, H; Hartmann, G; Gruener, S; Banner, DW; Benz, J; Gsell, B; Kuglstatter, A; Stihle, M; Thoma, R; Sanchez, RA; Iding, H; Wirz, B; Haap, W Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds. J Med Chem56:9789-801 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_MOUSE | Cats | Ctss |
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| Type: | Enzyme |
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| Mol. Mass.: | 38476.67 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | O70370 |
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| Residue: | 340 |
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| Sequence: | MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
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| BDBM50444317 |
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| n/a |
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| Name | BDBM50444317 |
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| Synonyms: | CHEMBL3093932 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16F3N3O3S |
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| Mol. Mass. | 387.377 |
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| SMILES | FC(F)(F)c1ccccc1S(=O)(=O)[C@H]1CN[C@@H](C1)C(=O)NC1(CC1)C#N |r| |
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| Structure | 
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