| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 1 |
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| Ligand | BDBM18512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1279072 (CHEMBL3094621) |
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| Ki | 145±n/a nM |
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| Citation |  Hume, WE; Shingaki, T; Takashima, T; Hashizume, Y; Okauchi, T; Katayama, Y; Hayashinaka, E; Wada, Y; Kusuhara, H; Sugiyama, Y; Watanabe, Y The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. Bioorg Med Chem21:7584-90 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug and toxin extrusion protein 1 |
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| Name: | Multidrug and toxin extrusion protein 1 |
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| Synonyms: | MATE-1 | Mate1 | S47A1_MOUSE | Slc47a1 | Solute carrier family 47 member 1 | mMATE-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61647.84 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_107975 |
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| Residue: | 567 |
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| Sequence: | MERTEESAPGPGGADAASERRGLRCLLLPGFLEELRALLVLAGPAFLAQLMMFLISFISS
VFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGT
LILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLN
QGIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRL
HQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYE
LAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDL
VGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIG
LPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKRACQQAQVHANLKVNVA
LNSAVSHEPAHPVCPESHGEIMMTDLEKKDETQLDQPMNQQQALPIRPKDSNKLSGKQLA
LRRGLLLLGVVLVLVGGILVRVYIRIE
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| BDBM18512 |
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| n/a |
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| Name | BDBM18512 |
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| Synonyms: | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL36 | Pyrimethamine (Pyr) | US11530198, Example Pyrimethamine | cid_4993 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13ClN4 |
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| Mol. Mass. | 248.711 |
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| SMILES | CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 |
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| Structure | 
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