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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A
LigandBDBM50444384
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1279586 (CHEMBL3097668)
IC50>10000±n/a nM
Citation Anderson, KChen, YChen, ZDominique, RGlenn, KHe, YJanson, CLuk, KCLukacs, CPolonskaia, AQiao, QRailkar, ARossman, PSun, HXiang, QVilenchik, MWovkulich, PZhang, X Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett23:6610-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Name:Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms:DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH
Type:Enzyme
Mol. Mass.:85616.61
Organism:Homo sapiens (Human)
Description:Q13627
Residue:763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
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  Blast E-value cutoff:
BDBM50444384
n/a
NameBDBM50444384
Synonyms:CHEMBL3094443
TypeSmall organic molecule
Emp. Form.C17H13ClN4O5
Mol. Mass.388.762
SMILESCOC(=O)c1ccc(Cl)c(c1)C(=O)Nc1cc2cnc(OC)nc2[nH]c1=O
Structure
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