| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50444410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1279808 (CHEMBL3095509) |
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| EC50 | 26000±n/a nM |
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| Citation |  Stevens, BD; Litchfield, J; Pfefferkorn, JA; Atkinson, K; Perreault, C; Amor, P; Bahnck, K; Berliner, MA; Calloway, J; Carlo, A; Derksen, DR; Filipski, KJ; Gumkowski, M; Jassal, C; MacDougall, M; Murphy, B; Nkansah, P; Pettersen, J; Rotter, C; Zhang, Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett23:6588-92 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52101.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1279785 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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| BDBM50444410 |
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| n/a |
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| Name | BDBM50444410 |
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| Synonyms: | CHEMBL3091580 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4O5S |
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| Mol. Mass. | 432.493 |
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| SMILES | OC(=O)c1ccc(NC(=O)[C@H](CC2CCCC2)n2cnc(c2)S(=O)(=O)C2CC2)nc1 |r| |
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| Structure | 
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