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TargetGlucokinase/Glucokinase regulatory protein
LigandBDBM50444412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1279814
EC50 1350±n/a nM
Citation Stevens BDLitchfield JPfefferkorn JAAtkinson KPerreault CAmor PBahnck KBerliner MACalloway JCarlo ADerksen DRFilipski KJGumkowski MJassal CMacDougall MMurphy BNkansah PPettersen JRotter CZhang Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett 23:6588-92 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucokinase/Glucokinase regulatory protein
Name:Glucokinase/Glucokinase regulatory protein
Synonyms:Glucokinase (GCK) | Glucokinase (GK) | HK IV | HK4 | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52175.81
Organism:Homo sapiens (Human)
Description:P35557
Residue:465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50444412
n/a
NameBDBM50444412
Synonyms:CHEMBL3091584
TypeSmall organic molecule
Emp. Form.C20H24N4O6S
Mol. Mass.448.493
SMILESOC(=O)c1ccc(NC(=O)[C@H](CC2CCOCC2)n2cnc(c2)S(=O)(=O)C2CC2)nc1 |r|
Structure
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