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TargetHexokinase-4
LigandBDBM50444412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1279814 (CHEMBL3095515)
EC50 1350±n/a nM
Citation Stevens, BDLitchfield, JPfefferkorn, JAAtkinson, KPerreault, CAmor, PBahnck, KBerliner, MACalloway, JCarlo, ADerksen, DRFilipski, KJGumkowski, MJassal, CMacDougall, MMurphy, BNkansah, PPettersen, JRotter, CZhang, Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett23:6588-92 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52175.81
Organism:Homo sapiens (Human)
Description:P35557
Residue:465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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  Blast E-value cutoff:
BDBM50444412
n/a
NameBDBM50444412
Synonyms:CHEMBL3091584
TypeSmall organic molecule
Emp. Form.C20H24N4O6S
Mol. Mass.448.493
SMILESOC(=O)c1ccc(NC(=O)[C@H](CC2CCOCC2)n2cnc(c2)S(=O)(=O)C2CC2)nc1 |r|
Structure
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