Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50444412 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1279814 (CHEMBL3095515) |
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EC50 | 1350±n/a nM |
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Citation | Stevens, BD; Litchfield, J; Pfefferkorn, JA; Atkinson, K; Perreault, C; Amor, P; Bahnck, K; Berliner, MA; Calloway, J; Carlo, A; Derksen, DR; Filipski, KJ; Gumkowski, M; Jassal, C; MacDougall, M; Murphy, B; Nkansah, P; Pettersen, J; Rotter, C; Zhang, Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett23:6588-92 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50444412 |
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n/a |
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Name | BDBM50444412 |
Synonyms: | CHEMBL3091584 |
Type | Small organic molecule |
Emp. Form. | C20H24N4O6S |
Mol. Mass. | 448.493 |
SMILES | OC(=O)c1ccc(NC(=O)[C@H](CC2CCOCC2)n2cnc(c2)S(=O)(=O)C2CC2)nc1 |r| |
Structure |
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