| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50444498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1277742 (CHEMBL3097342) |
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| Ki | 3.2±n/a nM |
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| Citation |  Wilson, DM; Apps, J; Bailey, N; Bamford, MJ; Beresford, IJ; Brackenborough, K; Briggs, MA; Brough, S; Calver, AR; Crook, B; Davis, RK; Davis, RP; Davis, S; Dean, DK; Harris, L; Heslop, T; Holland, V; Jeffrey, P; Panchal, TA; Parr, CA; Quashie, N; Schogger, J; Sehmi, SS; Stean, TO; Steadman, JG; Trail, B; Wald, J; Worby, A; Takle, AK; Witherington, J; Medhurst, AD Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett23:6890-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50444498 |
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| n/a |
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| Name | BDBM50444498 |
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| Synonyms: | CHEMBL3092648 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O |
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| Mol. Mass. | 360.4522 |
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| SMILES | C1CC(C1)N1CCc2ccc(Oc3ccc(cn3)-n3cccn3)cc2CC1 |
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| Structure | 
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