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TargetHistamine H3 receptor
LigandBDBM50444511
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1277742 (CHEMBL3097342)
Ki 4.0±n/a nM
Citation Wilson, DMApps, JBailey, NBamford, MJBeresford, IJBrackenborough, KBriggs, MABrough, SCalver, ARCrook, BDavis, RKDavis, RPDavis, SDean, DKHarris, LHeslop, THolland, VJeffrey, PPanchal, TAParr, CAQuashie, NSchogger, JSehmi, SSStean, TOSteadman, JGTrail, BWald, JWorby, ATakle, AKWitherington, JMedhurst, AD Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett23:6890-6 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:HH3R | HRH3_RAT | Hrh3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48607.98
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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  Blast E-value cutoff:
BDBM50444511
n/a
NameBDBM50444511
Synonyms:CHEMBL3092838
TypeSmall organic molecule
Emp. Form.C21H23N3O
Mol. Mass.333.4268
SMILESCc1nc(Oc2ccc3CCN(CCc3c2)C2CCC2)ccc1C#N
Structure
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