| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM50444550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1281886 (CHEMBL3101039) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Meredith, EL; Ksander, G; Monovich, LG; Papillon, JP; Liu, Q; Miranda, K; Morris, P; Rao, C; Burgis, R; Capparelli, M; Hu, QY; Singh, A; Rigel, DF; Jeng, AY; Beil, M; Fu, F; Hu, CW; LaSala, D Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors. ACS Med Chem Lett4:1203-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58260.64 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_224979 |
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| Residue: | 510 |
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| Sequence: | MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWL
KMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRR
MHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLE
ALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSM
FKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIV
AALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEAS
IAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSM
GRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQV
ETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
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| BDBM50444550 |
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| n/a |
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| Name | BDBM50444550 |
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| Synonyms: | CHEMBL3099704 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18FN3 |
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| Mol. Mass. | 331.3861 |
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| SMILES | Fc1ccc(cc1)-c1cc(ccc1[C@H]1CCCCc2cncn12)C#N |r| |
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| Structure | 
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