Reaction Details |
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Target | DNA ligase |
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Ligand | BDBM50444574 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1281919 (CHEMBL3101193) |
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IC50 | 130000±n/a nM |
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Citation | Howard, S; Amin, N; Benowitz, AB; Chiarparin, E; Cui, H; Deng, X; Heightman, TD; Holmes, DJ; Hopkins, A; Huang, J; Jin, Q; Kreatsoulas, C; Martin, AC; Massey, F; McCloskey, L; Mortenson, PN; Pathuri, P; Tisi, D; Williams, PA Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase. ACS Med Chem Lett4:1208-12 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA ligase |
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Name: | DNA ligase |
Synonyms: | DNLJ_STAAU | Polydeoxyribonucleotide synthase [NAD(+)] | lig | ligA |
Type: | PROTEIN |
Mol. Mass.: | 75059.93 |
Organism: | Staphylococcus aureus |
Description: | ChEMBL_1281598 |
Residue: | 667 |
Sequence: | MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEYKTVDSPTV
RVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSL
KYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNE
EKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELD
KLGFTTNKNRARVNNIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSP
RWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDR
DIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCI
NPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRM
GQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVE
IHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTG
KLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVD
KQNELNS
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BDBM50444574 |
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n/a |
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Name | BDBM50444574 |
Synonyms: | CHEMBL3099708 |
Type | Small organic molecule |
Emp. Form. | C8H8N4O |
Mol. Mass. | 176.1753 |
SMILES | COc1cccc(n1)-c1nnc[nH]1 |
Structure |
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