| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
|---|
| Ligand | BDBM50444595 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1282257 (CHEMBL3102606) |
|---|
| IC50 | >40000±n/a nM |
|---|
| Citation |  Ye, Q; Shen, Y; Zhou, Y; Lv, D; Gao, J; Li, J; Hu, Y Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3ß (GSK-3ß) inhibitors. Eur J Med Chem68:361-71 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 3 |
|---|
| Name: | Mitogen-activated protein kinase 3 |
|---|
| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43136.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | curated by PDB 4QTB |
|---|
| Residue: | 379 |
|---|
| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
|
|
|
|---|
| BDBM50444595 |
|---|
| n/a |
|---|
| Name | BDBM50444595 |
|---|
| Synonyms: | CHEMBL563560 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H19N7O2 |
|---|
| Mol. Mass. | 437.4534 |
|---|
| SMILES | Cn1cc(C2=C(C(=O)NC2=O)c2nn(CCn3ccnc3)c3ncccc23)c2ccccc12 |t:4| |
|---|
| Structure | 
|
|---|
Search and Browse
