| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kallikrein-5 [D153N] |
|---|
| Ligand | BDBM50444598 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1282456 (CHEMBL3100883) |
|---|
| IC50 | 125000±n/a nM |
|---|
| Citation |  Tan, X; Bertonati, C; Qin, L; Furio, L; El Amri, C; Hovnanian, A; Reboud-Ravaux, M; Villoutreix, BO Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins. Eur J Med Chem70:661-8 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kallikrein-5 [D153N] |
|---|
| Name: | Kallikrein-5 [D153N] |
|---|
| Synonyms: | KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32031.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1282456 |
|---|
| Residue: | 293 |
|---|
| Sequence: | MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARS
DDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGH
YSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPS
AGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDS
CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
|
|
|
|---|
| BDBM50444598 |
|---|
| n/a |
|---|
| Name | BDBM50444598 |
|---|
| Synonyms: | CHEMBL3099878 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N4O4 |
|---|
| Mol. Mass. | 418.4452 |
|---|
| SMILES | COc1cc(\C=C(\C#N)c2nc3ccccc3[nH]2)ccc1OCC(=O)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
