| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50444611 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1283184 (CHEMBL3101095) |
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| Ki | 0.700000±n/a nM |
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| Citation |  Mercer, SP; Roecker, AJ; Garson, S; Reiss, DR; Meacham Harrell, C; Murphy, KL; Bruno, JG; Bednar, RA; Lemaire, W; Cui, D; Cabalu, TD; Tang, C; Prueksaritanont, T; Hartman, GD; Young, SD; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs). Bioorg Med Chem Lett23:6620-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50444611 |
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| n/a |
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| Name | BDBM50444611 |
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| Synonyms: | CHEMBL3099893 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O3 |
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| Mol. Mass. | 453.5323 |
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| SMILES | COc1ccc(CNC(=O)c2cc(cnc2-c2cccnc2)-c2cc(C)cc(C)c2)cc1OC |
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| Structure | 
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