Reaction Details |
| Report a problem with these data |
Target | Nicotinamide phosphoribosyltransferase |
---|
Ligand | BDBM50444654 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1281258 (CHEMBL3100993) |
---|
IC50 | 1.7±n/a nM |
---|
Citation | Zheng, X; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Han, B; Ho, YC; Kley, N; Lin, J; Reynolds, DJ; Sharma, G; Smith, CC; Wang, Z; Dragovich, PS; Oh, A; Wang, W; Zak, M; Wang, Y; Yuen, PW; Bair, KW Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg Med Chem Lett24:337-43 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nicotinamide phosphoribosyltransferase |
---|
Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
|
|
|
BDBM50444654 |
---|
n/a |
---|
Name | BDBM50444654 |
Synonyms: | CHEMBL3098517 |
Type | Small organic molecule |
Emp. Form. | C23H23N7O3S |
Mol. Mass. | 477.539 |
SMILES | O=S(=O)(c1ccc(CNC(NC#N)=Nc2ccncc2)cc1)c1ccc(nc1)N1CCOCC1 |w:13.13| |
Structure |
|