| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl diphosphate synthase |
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| Ligand | BDBM12576 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1282366 (CHEMBL3100417) |
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| IC50 | 74±n/a nM |
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| Citation |  Ferrer-Casal, M; Li, C; Galizzi, M; Stortz, CA; Szajnman, SH; Docampo, R; Moreno, SN; Rodriguez, JB New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorg Med Chem22:398-405 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl diphosphate synthase |
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| Name: | Farnesyl diphosphate synthase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69493.18 |
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| Organism: | Toxoplasma gondii |
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| Description: | ChEMBL_1282507 |
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| Residue: | 646 |
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| Sequence: | MVDAVSLVSCRARHSHSLFAFSLSRRSCIQKHRFFSYVKSVPSSLPSPSSSSSPFTLSPR
RRCLPPLVLPLEAAGHLPPALHSGSGISCPRSSSLSLSSSSPMRAPPSISLGLPPAQRPS
LCFSPTSRLSAPVSPWSFSRQLSLATLAPLASVSSWKKAAALPKPDGAAAVSDERTSAER
ADALAGAWRASASHVEDRFKQAFPEVRGTLLSHIAGLDLPASLSARLLSYYARLLDYTCS
GGKLTRGILVLYAAAAASHAPVLPPPSPSPAAAPASSASSVSSSPCSSSLAESERVPGSA
LSPALPPSSFRCLAALGWCVELLQSCFLVMDDVMDHSLTRRGKQCWYRCDGIGVSNAVND
SLVLEAAVYRVLREYLGDHPAYVQLQDLLLGNTFTTLIGQHLDSEDALAALSEASQNLES
RQSEDNSSASSATAAGSSLLRDASLSDKDFTHHSYVSSSLSSSRSSPSLSASSLPSSEVL
AQKLADRQATVARLKTSHYSFYLPTALGMTYGGLTDPALMAQAKELCLAIGEYFQVQDDY
LDCFSDPKISGKIGSDIQEKKCCWLFVQAVRRASREDLAQLLRVYGQPEYVDWVKDLYRR
LDLTSLYFQYEEETLAKLRRSVSSFPHDGMKAFFGLVLGRLHKRQK
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| BDBM12576 |
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| n/a |
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| Name | BDBM12576 |
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| Synonyms: | Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H11NO7P2 |
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| Mol. Mass. | 283.1123 |
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| SMILES | OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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