Reaction Details |
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Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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Ligand | BDBM50444966 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1281519 (CHEMBL3102085) |
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Ki | 1.4±n/a nM |
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Citation | Kim, JJ; Wood, MR; Stachel, SJ; de Leon, P; Nomland, A; Stump, CA; McWherter, MA; Schirripa, KM; Moore, EL; Salvatore, CA; Selnick, HG (E)-Alkenes as replacements of amide bonds: development of novel and potent acyclic CGRP receptor antagonists. Bioorg Med Chem Lett24:258-61 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 327200 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Calcitonin gene-related peptide type 1 receptor |
Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52980.45 |
Organism: | Homo sapiens (Human) |
Description: | Q16602 |
Residue: | 461 |
Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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Component 2 |
Name: | Receptor activity-modifying protein 1 |
Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 16992.80 |
Organism: | Homo sapiens (Human) |
Description: | EBI_100673 |
Residue: | 148 |
Sequence: | MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
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BDBM50444966 |
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n/a |
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Name | BDBM50444966 |
Synonyms: | CHEMBL3099937 |
Type | Small organic molecule |
Emp. Form. | C30H34N4O2 |
Mol. Mass. | 482.6166 |
SMILES | C[C@@H](N(CCCc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C)c1ccccc1 |r| |
Structure |
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