| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50445004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1281524 (CHEMBL3102090) |
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| IC50 | 0.890000±n/a nM |
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| Citation |  Hossain, N; Mensonides-Harsema, M; Cooper, ME; Eriksson, T; Ivanova, S; Bergström, L Structure activity relationships of fused bicyclic and urea derivatives of spirocyclic compounds as potent CCR1 antagonists. Bioorg Med Chem Lett24:108-12 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50445004 |
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| n/a |
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| Name | BDBM50445004 |
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| Synonyms: | CHEMBL3099945 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30ClN3O5 |
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| Mol. Mass. | 487.976 |
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| SMILES | O[C@H](COc1cc(O)ccc1NC(=O)NC1CC1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1 |r| |
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| Structure | 
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