| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM31892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1282431 (CHEMBL3100732) |
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| EC50 | 120±n/a nM |
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| Citation |  Desphande, A; Xia, G; Boerma, LJ; Vines, KK; Atigadda, VR; Lobo-Ruppert, S; Grubbs, CJ; Moeinpour, FL; Smith, CD; Christov, K; Brouillette, WJ; Muccio, DD Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg Med Chem22:178-85 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51273.78 |
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| Organism: | RAT |
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| Description: | NR2B Channel Blocker 0 RAT::Q05343 |
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| Residue: | 467 |
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| Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
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| BDBM31892 |
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| n/a |
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| Name | BDBM31892 |
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| Synonyms: | 9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin | alitretinoin |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28O2 |
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| Mol. Mass. | 300.4351 |
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| SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| |
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| Structure | 
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