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TargetSerine/threonine-protein kinase PIM
LigandBDBM50445124
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1284447
Ki 0.002000±n/a nM
Citation Burger MTHan WLan JNishiguchi GBellamacina CLindval MAtallah GDing YMathur MMcBride CBeans ELMuller KTamez VZhang YHuh KFeucht PZavorotinskaya TDai YHolash JCastillo JLangowski JWang YChen MYGarcia PD Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett 4:1193-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PIM
Name:Serine/threonine-protein kinase PIM
Synonyms:2.7.11.1 | PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:45417.87
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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  Blast E-value cutoff:
BDBM50445124
n/a
NameBDBM50445124
Synonyms:CHEMBL3103868
TypeSmall organic molecule
Emp. Form.C22H22F2N6O
Mol. Mass.424.4465
SMILESN[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F |r|
Structure
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