Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-1 | ||
Ligand | BDBM106896 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1284449 (CHEMBL3106177) | ||
Ki | 0.001000±n/a nM | ||
Citation | Burger, MT; Han, W; Lan, J; Nishiguchi, G; Bellamacina, C; Lindval, M; Atallah, G; Ding, Y; Mathur, M; McBride, C; Beans, EL; Muller, K; Tamez, V; Zhang, Y; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Holash, J; Castillo, J; Langowski, J; Wang, Y; Chen, MY; Garcia, PD Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett4:1193-7 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-1 | |||
Name: | Serine/threonine-protein kinase pim-1 | ||
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
Type: | Protein | ||
Mol. Mass.: | 35681.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11309 | ||
Residue: | 313 | ||
Sequence: |
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BDBM106896 | |||
n/a | |||
Name | BDBM106896 | ||
Synonyms: | US8592455, 96 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H22F3N5O2 | ||
Mol. Mass. | 457.4483 | ||
SMILES | C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:7.8,wD:1.0,5.5,(-6,2.69,;-4.67,1.93,;-4.67,.38,;-3.33,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,2.69,;-3.33,4.23,;-3.33,-1.93,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;.67,-4.23,;2,-1.93,;3.33,-2.69,;4.67,-1.93,;4.67,-.38,;6,.38,;3.33,.38,;2,-.38,;3.33,1.93,;4.67,2.69,;6,1.93,;4.67,4.23,;3.33,5,;2,4.23,;2,2.69,;.67,1.93,)| | ||
Structure |