| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50005209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284452 (CHEMBL3106180) |
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| Ki | <1±n/a nM |
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| Citation |  Burger, MT; Han, W; Lan, J; Nishiguchi, G; Bellamacina, C; Lindval, M; Atallah, G; Ding, Y; Mathur, M; McBride, C; Beans, EL; Muller, K; Tamez, V; Zhang, Y; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Holash, J; Castillo, J; Langowski, J; Wang, Y; Chen, MY; Garcia, PD Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett4:1193-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50005209 |
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| n/a |
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| Name | BDBM50005209 |
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| Synonyms: | CHEMBL3103867 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN6O |
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| Mol. Mass. | 406.456 |
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| SMILES | N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F |r| |
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| Structure | 
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