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TargetP2Y purinoceptor 1
LigandBDBM50445202
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1284787 (CHEMBL3107684)
Ki 16±n/a nM
Citation Qiao, JXWang, TCRuel, RThibeault, CL'Heureux, ASchumacher, WASpronk, SAHiebert, SBouthillier, GLloyd, JPi, ZSchnur, DMAbell, LMHua, JPrice, LALiu, EWu, QSteinbacher, TEBostwick, JSChang, MZheng, JGao, QMa, BMcDonnell, PAHuang, CSRehfuss, RWexler, RRLam, PY Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. J Med Chem56:9275-95 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 1
Name:P2Y purinoceptor 1
Synonyms:ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:Enzyme
Mol. Mass.:42090.25
Organism:Homo sapiens (Human)
Description:P47900
Residue:373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
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  Blast E-value cutoff:
BDBM50445202
n/a
NameBDBM50445202
Synonyms:CHEMBL3103627
TypeSmall organic molecule
Emp. Form.C24H23F3N4O2
Mol. Mass.456.4602
SMILESCC1(C)CCN(c2ccccc12)c1ncccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1
Structure
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