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TargetP2X purinoceptor 1
LigandBDBM50445214
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1284760 (CHEMBL3107657)
IC50 1600±n/a nM
Citation Qiao, JXWang, TCRuel, RThibeault, CL'Heureux, ASchumacher, WASpronk, SAHiebert, SBouthillier, GLloyd, JPi, ZSchnur, DMAbell, LMHua, JPrice, LALiu, EWu, QSteinbacher, TEBostwick, JSChang, MZheng, JGao, QMa, BMcDonnell, PAHuang, CSRehfuss, RWexler, RRLam, PY Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. J Med Chem56:9275-95 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 1
Name:P2X purinoceptor 1
Synonyms:ATP receptor | P2RX1 | P2RX1_HUMAN | P2X1 | Purinergic receptor | Purinergic, P2X
Type:Enzyme Catalytic Domain
Mol. Mass.:44992.65
Organism:Homo sapiens (Human)
Description:Purinergic, P2X 0 HUMAN::P51575
Residue:399
Sequence:
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50445214
n/a
NameBDBM50445214
Synonyms:CHEMBL3104636
TypeSmall organic molecule
Emp. Form.C31H35F3N4O2
Mol. Mass.552.6304
SMILESCC(C)(C)CN1CCC2(CN(c3ccccc23)c2ccccc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Structure
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