Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPerforin-1
LigandBDBM50445276
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1285138 (CHEMBL3106784)
IC50 550±n/a nM
Citation Spicer, JALena, GLyons, DMHuttunen, KMMiller, CKO'Connor, PDBull, MHelsby, NJamieson, SMDenny, WACiccone, ABrowne, KALopez, JARudd-Schmidt, JVoskoboinik, ITrapani, JA Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem56:9542-55 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Perforin-1
Name:Perforin-1
Synonyms:PERF_HUMAN | PFP | PRF1
Type:PROTEIN
Mol. Mass.:61392.32
Organism:Homo sapiens (Human)
Description:ChEMBL_1285138
Residue:555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50445276
n/a
NameBDBM50445276
Synonyms:CHEMBL3103917
TypeSmall organic molecule
Emp. Form.C19H15N3O4S2
Mol. Mass.413.47
SMILESCCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: