| Reaction Details |
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 | Report a problem with these data |
| Target | Perforin-1 |
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| Ligand | BDBM50445303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1285138 (CHEMBL3106784) |
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| IC50 | 790±n/a nM |
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| Citation |  Spicer, JA; Lena, G; Lyons, DM; Huttunen, KM; Miller, CK; O'Connor, PD; Bull, M; Helsby, N; Jamieson, SM; Denny, WA; Ciccone, A; Browne, KA; Lopez, JA; Rudd-Schmidt, J; Voskoboinik, I; Trapani, JA Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem56:9542-55 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Perforin-1 |
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| Name: | Perforin-1 |
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| Synonyms: | PERF_HUMAN | PFP | PRF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61392.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1285138 |
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| Residue: | 555 |
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| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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| BDBM50445303 |
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| n/a |
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| Name | BDBM50445303 |
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| Synonyms: | CHEMBL3102870 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11N3O2S2 |
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| Mol. Mass. | 329.397 |
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| SMILES | NC(=O)c1cccc(c1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 |
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| Structure | 
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