| Reaction Details |
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 | Report a problem with these data |
| Target | Ezrin |
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| Ligand | BDBM50445469 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284145 (CHEMBL3107613) |
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| Kd | 9100±n/a nM |
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| Citation |  Paige, M; Kosturko, G; Bulut, G; Miessau, M; Rahim, S; Toretsky, JA; Brown, ML; Üren, A Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorg Med Chem22:478-87 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ezrin |
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| Name: | Ezrin |
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| Synonyms: | Cytovillin | EZR | EZRI_HUMAN | VIL2 | Villin-2 | p81 |
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| Type: | Protein |
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| Mol. Mass.: | 69408.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15311 |
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| Residue: | 586 |
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| Sequence: | MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
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| BDBM50445469 |
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| n/a |
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| Name | BDBM50445469 |
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| Synonyms: | CHEMBL3104721 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13BrN2O2 |
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| Mol. Mass. | 357.201 |
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| SMILES | Oc1cc(N=CCc2cccc(Br)c2)c(O)c2ncccc12 |w:4.3| |
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| Structure | 
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