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TargetEzrin
LigandBDBM50445470
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1284145 (CHEMBL3107613)
Kd 40100±n/a nM
Citation Paige, MKosturko, GBulut, GMiessau, MRahim, SToretsky, JABrown, MLÜren, A Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorg Med Chem22:478-87 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ezrin
Name:Ezrin
Synonyms:Cytovillin | EZR | EZRI_HUMAN | VIL2 | Villin-2 | p81
Type:Protein
Mol. Mass.:69408.95
Organism:Homo sapiens (Human)
Description:P15311
Residue:586
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50445470
n/a
NameBDBM50445470
Synonyms:CHEMBL3104716
TypeSmall organic molecule
Emp. Form.C17H12Br2N2O3
Mol. Mass.452.097
SMILESOc1cc(N=CCc2cc(Br)c(O)c(Br)c2)c(O)c2cnccc12 |w:4.3|
Structure
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