| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein 75 kDa, mitochondrial |
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| Ligand | BDBM20800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284500 (CHEMBL3106548) |
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| Ki | 62±n/a nM |
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| Citation |  Ernst, JT; Liu, M; Zuccola, H; Neubert, T; Beaumont, K; Turnbull, A; Kallel, A; Vought, B; Stamos, D Correlation between chemotype-dependent binding conformations of HSP90a/ß and isoform selectivity-Implications for the structure-based design of HSP90a/ß selective inhibitors for treating neurodegenerative diseases. Bioorg Med Chem Lett24:204-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock protein 75 kDa, mitochondrial |
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| Name: | Heat shock protein 75 kDa, mitochondrial |
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| Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80120.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1478164 |
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| Residue: | 704 |
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| Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
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| BDBM20800 |
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| n/a |
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| Name | BDBM20800 |
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| Synonyms: | 2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine | CHEMBL467399 | hsp90_107 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15ClN6O |
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| Mol. Mass. | 318.762 |
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| SMILES | COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C |
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| Structure | 
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