| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50445880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1285942 (CHEMBL3106085) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent ROR¿t inhibitors. Bioorg Med Chem22:692-702 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58133.31 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_103664 |
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| Residue: | 516 |
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| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
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| BDBM50445880 |
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| n/a |
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| Name | BDBM50445880 |
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| Synonyms: | CHEMBL3105670 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21ClFNO4S2 |
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| Mol. Mass. | 542.041 |
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| SMILES | CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2F)-c2cccc(Cl)c2)cc1 |
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| Structure | 
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