Reaction Details |
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Target | Aldo-keto reductase family 1 member C4 |
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Ligand | BDBM50446022 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1283743 (CHEMBL3108468) |
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IC50 | >30000±n/a nM |
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Citation | Flanagan, JU; Atwell, GJ; Heinrich, DM; Brooke, DG; Silva, S; Rigoreau, LJ; Trivier, E; Turnbull, AP; Raynham, T; Jamieson, SM; Denny, WA Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem22:967-77 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member C4 |
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Name: | Aldo-keto reductase family 1 member C4 |
Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
Type: | Enzyme |
Mol. Mass.: | 37068.40 |
Organism: | Homo sapiens (Human) |
Description: | P17516 |
Residue: | 323 |
Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
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BDBM50446022 |
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n/a |
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Name | BDBM50446022 |
Synonyms: | CHEMBL3103335 |
Type | Small organic molecule |
Emp. Form. | C16H22ClN3O2 |
Mol. Mass. | 323.818 |
SMILES | Clc1ccc(CN2CCN(CC2)C(=O)N2CCOCC2)cc1 |
Structure |
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