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TargetAldo-keto reductase family 1 member C4
LigandBDBM50446026
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1283743 (CHEMBL3108468)
IC50>30000±n/a nM
Citation Flanagan, JUAtwell, GJHeinrich, DMBrooke, DGSilva, SRigoreau, LJTrivier, ETurnbull, APRaynham, TJamieson, SMDenny, WA Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem22:967-77 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member C4
Name:Aldo-keto reductase family 1 member C4
Synonyms:3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA
Type:Enzyme
Mol. Mass.:37068.40
Organism:Homo sapiens (Human)
Description:P17516
Residue:323
Sequence:
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
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  Blast E-value cutoff:
BDBM50446026
n/a
NameBDBM50446026
Synonyms:CHEMBL3103350
TypeSmall organic molecule
Emp. Form.C17H23N3O4
Mol. Mass.333.3822
SMILESCOC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)N1CCOCC1
Structure
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