| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent 6-phosphofructokinase |
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| Ligand | BDBM50446099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1288119 (CHEMBL3110579) |
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| IC50 | 730±n/a nM |
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| Citation |  Brimacombe, KR; Walsh, MJ; Liu, L; Vásquez-Valdivieso, MG; Morgan, HP; McNae, I; Fothergill-Gilmore, LA; Michels, PA; Auld, DS; Simeonov, A; Walkinshaw, MD; Shen, M; Boxer, MB Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett5:12-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent 6-phosphofructokinase |
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| Name: | ATP-dependent 6-phosphofructokinase |
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| Synonyms: | 6-phospho-1-fructokinase, putative | PFKA_TRYCC | pfk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53581.09 |
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| Organism: | Trypanosoma cruzi |
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| Description: | ChEMBL_108019 |
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| Residue: | 485 |
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| Sequence: | MENRLRDTSRVVRSHAAPLNEVTQEDLKVERLHGRKYMNPSKKHVMREEFSDKIEHIMHD
PRPQEGVHSELPVSISPLLCELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLT
AVNAYRVKRVIGFRFGYWGLSKKGSHTAMELYRTSVTSIHRYGGTILGSSRGPQDTSEMV
DTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFE
TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISE
DIVMALIQRRFETSRSCVIIVAEGFGQDWEGGTGGHDASGNKKLTDIGVVLTKRIQAWLR
KNKERYPNGTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGATNCIIALRYNSY
ILVPIKVATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEAISLVRERLIG
QLSKL
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| BDBM50446099 |
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| n/a |
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| Name | BDBM50446099 |
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| Synonyms: | CHEMBL3108859 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14Cl2N4O3S |
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| Mol. Mass. | 425.289 |
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| SMILES | Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccn[nH]2)cc1Cl |
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| Structure | 
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