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TargetATP-dependent 6-phosphofructokinase
LigandBDBM50446115
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1288119 (CHEMBL3110579)
IC50 1460±n/a nM
Citation Brimacombe, KRWalsh, MJLiu, LVásquez-Valdivieso, MGMorgan, HPMcNae, IFothergill-Gilmore, LAMichels, PAAuld, DSSimeonov, AWalkinshaw, MDShen, MBoxer, MB Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett5:12-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-dependent 6-phosphofructokinase
Name:ATP-dependent 6-phosphofructokinase
Synonyms:6-phospho-1-fructokinase, putative | PFKA_TRYCC | pfk
Type:PROTEIN
Mol. Mass.:53581.09
Organism:Trypanosoma cruzi
Description:ChEMBL_108019
Residue:485
Sequence:
MENRLRDTSRVVRSHAAPLNEVTQEDLKVERLHGRKYMNPSKKHVMREEFSDKIEHIMHD
PRPQEGVHSELPVSISPLLCELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLT
AVNAYRVKRVIGFRFGYWGLSKKGSHTAMELYRTSVTSIHRYGGTILGSSRGPQDTSEMV
DTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFE
TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISE
DIVMALIQRRFETSRSCVIIVAEGFGQDWEGGTGGHDASGNKKLTDIGVVLTKRIQAWLR
KNKERYPNGTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGATNCIIALRYNSY
ILVPIKVATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEAISLVRERLIG
QLSKL
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  Blast E-value cutoff:
BDBM50446115
n/a
NameBDBM50446115
Synonyms:CHEMBL3108844
TypeSmall organic molecule
Emp. Form.C18H16ClN3O4S
Mol. Mass.405.855
SMILESCc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)cc3)cc2)no1
Structure
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