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Target6-phospho-1-fructokinase, putative
LigandBDBM50446116
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1288119
IC50 2590±n/a nM
Citation Brimacombe KRWalsh MJLiu LVásquez-Valdivieso MGMorgan HPMcNae IFothergill-Gilmore LAMichels PAAuld DSSimeonov AWalkinshaw MDShen MBoxer MB Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett 5:12-7 (2014) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
6-phospho-1-fructokinase, putative
Name:6-phospho-1-fructokinase, putative
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:53606.14
Organism:Trypanosoma cruzi
Description:ChEMBL_108019
Residue:485
Sequence:
MENRLRDTSRVVRSHAAPLNEVTQEDLRVERLHGRKYMNPSKKHVMREEFSDKIEHIMHD
PRPQEGVHSELPVSISPLLCELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLT
AVNAYRVKRVIGFRFGYWGLSKKGSHTAMELYRTSVTSIHRYGGTILGSSRGPQDPSEMV
DTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGVNLAVFGIPKTIDNDLSFSHRTFGFE
TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISE
DIVMALIQRRFETSRSCVIIVAEGFGQDWEGGTGGHDASGNKKLTDIGVVLTKRIQAWLR
KNKERYPSGTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGATNCIIALRYNSY
ILVPIKVATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEAISLVRERLIG
QLSKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50446116
n/a
NameBDBM50446116
Synonyms:CHEMBL3108843
TypeSmall organic molecule
Emp. Form.C18H16ClN3O4S
Mol. Mass.405.855
SMILESCc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3cccc(Cl)c3)cc2)no1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: