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TargetATP-dependent 6-phosphofructokinase
LigandBDBM50446127
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1288121 (CHEMBL3110581)
IC50 33000±n/a nM
Citation Brimacombe, KRWalsh, MJLiu, LVásquez-Valdivieso, MGMorgan, HPMcNae, IFothergill-Gilmore, LAMichels, PAAuld, DSSimeonov, AWalkinshaw, MDShen, MBoxer, MB Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett5:12-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-dependent 6-phosphofructokinase
Name:ATP-dependent 6-phosphofructokinase
Synonyms:6-phospho-1-fructokinase | PFKA_TRYBB | pfk
Type:PROTEIN
Mol. Mass.:53537.94
Organism:Trypanosoma brucei
Description:ChEMBL_1288121
Residue:487
Sequence:
MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIM
YNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSIT
LTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKE
MVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFG
FQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPI
SEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAF
LKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHN
NYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRL
HEELAKL
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  Blast E-value cutoff:
BDBM50446127
n/a
NameBDBM50446127
Synonyms:CHEMBL3108832
TypeSmall organic molecule
Emp. Form.C17H19Cl2N3O4S
Mol. Mass.432.321
SMILESCc1cc(NS(=O)(=O)C2CCN(CC2)C(=O)Cc2ccc(Cl)c(Cl)c2)no1
Structure
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